Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	736496
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	MAPT
Name:	microtubule associated protein tau

Acc ID:	CHEBI:44658
Term:	okadaic acid
Definition:	A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
Chemical ID:	MESH:D019319

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
MAPT	increases phosphorylation	EXP		6480464	CTD	Okadaic Acid results in increased phosphorylation of MAPT protein	PMID:21715663 PMID:26836014 PMID:7723735
MAPT	multiple interactions	EXP		6480464	CTD	[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]; [N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]; [Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT protein; [PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]; morroniside inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]	PMID:21715663 PMID:26836014 PMID:7723735
MAPT	affects phosphorylation	ISO	Mapt (Mus musculus)	6480464	CTD	Okadaic Acid affects the phosphorylation of MAPT protein	PMID:21934130 PMID:27050422
MAPT	increases phosphorylation	ISO	Mapt (Rattus norvegicus)	6480464	CTD	Okadaic Acid results in increased phosphorylation of MAPT protein	PMID:26732598 PMID:7723735
MAPT	multiple interactions	ISO	Mapt (Rattus norvegicus)	6480464	CTD	[Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT protein; Okadaic Acid inhibits the reaction [Ionomycin results in decreased phosphorylation of MAPT protein]; Okadaic Acid inhibits the reaction [Potassium Chloride results in decreased phosphorylation of MAPT protein]	PMID:7723735 PMID:9200503
MAPT	multiple interactions	ISO	Mapt (Mus musculus)	6480464	CTD	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lithium Chloride inhibits the reaction [Okadaic Acid affects the phosphorylation of MAPT protein]]; Lithium Chloride inhibits the reaction [Okadaic Acid affects the phosphorylation of MAPT protein]; Okadaic Acid inhibits the reaction [Ionomycin results in decreased phosphorylation of MAPT protein]; Quercetin inhibits the reaction [Okadaic Acid affects the phosphorylation of MAPT protein]	PMID:27050422 PMID:9200503

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