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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:44658
Term: okadaic acid
Definition: A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
Chemical ID: MESH:D019319
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junincreases expressionISOJun (Mus musculus)6480464CTDOkadaic Acid results in increased expression of JUN mRNAPMID:19000923
Junincreases expressionISOJUN (Homo sapiens)6480464CTDOkadaic Acid results in increased expression of JUN mRNAPMID:28939011 PMID:31115591
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDOkadaic Acid inhibits the reaction [Tretinoin results in decreased phosphorylation of JUN protein]PMID:16052510
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