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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:44658
Term: okadaic acid
Definition: A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
Chemical ID: MESH:D019319
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:692106480464CTDOkadaic Acid promotes the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA], Okadaic Acid promotes the reaction [lithocholic acid acetate results in decreased expression of CYP7A1 mRNA]

PMID:20371703
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.