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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1603864
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP4A22
Name: cytochrome P450 family 4 subfamily A member 22
Acc ID: CHEBI:44658
Term: okadaic acid
Definition: A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
Chemical ID: MESH:D019319
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP4A22multiple interactionsISOCyp4a1 (Rattus norvegicus)6480464CTDOkadaic Acid inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYP4A1 mRNA]; Okadaic Acid inhibits the reaction [Nafenopin results in increased expression of CYP4A1 mRNA]PMID:18079279
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