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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11132
Species: Mus musculus
RGD Object: Gene
Symbol: Ppp1ca
Name: protein phosphatase 1 catalytic subunit alpha
Acc ID: CHEBI:44658
Term: okadaic acid
Definition: A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
Chemical ID: MESH:D019319
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp1cadecreases activityISOPpp1ca (Rattus norvegicus)6480464CTDOkadaic Acid results in decreased activity of PPP1CA proteinPMID:15767308
Ppp1camultiple interactionsISOPPP1CA (Homo sapiens)6480464CTDOkadaic Acid inhibits the reaction [Amiloride results in decreased phosphorylation of PPP1CA protein]PMID:16059913
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