GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccne1 | increases cleavage | ISO | CCNE1 (Homo sapiens) | 6480464 | CTD | afimoxifene results in increased cleavage of CCNE1 protein | PMID:23624423 | Ccne1 | multiple interactions | ISO | CCNE1 (Homo sapiens) | 6480464 | CTD | [afimoxifene co-treated with lapatinib] promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; afimoxifene promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; GPER1 protein affects the reaction [afimoxifene results in increased cleavage of CCNE1 protein]; U 0126 inhibits the reaction [afimoxifene results in increased cleavage of CCNE1 protein] | PMID:15665275 PMID:23624423 | |
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