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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730826
Species: Homo sapiens
RGD Object: Gene
Symbol: ESRRA
Name: estrogen related receptor alpha
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESRRAaffects bindingEXP 6480464CTDafimoxifene binds to ESRRA protein mutant formPMID:11447273
ESRRAmultiple interactionsEXP 6480464CTDafimoxifene binds to and results in decreased activity of [ESRRG protein binds to ESRRA protein]PMID:14751226
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