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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620242
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sgk3
Name: serum/glucocorticoid regulated kinase family, member 3
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceISORGD:13541886480464CTDSGK3 results in decreased susceptibility to afimoxifene

PMID:21233418
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