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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2875
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igfbp4
Name: insulin-like growth factor binding protein 4
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igfbp4increases expressionISOIGFBP4 (Homo sapiens)6480464CTDafimoxifene results in increased expression of IGFBP4 mRNAPMID:15072547 PMID:19901195
Igfbp4multiple interactionsISOIGFBP4 (Homo sapiens)6480464CTDafimoxifene inhibits the reaction [Estrogens results in increased expression of IGFBP4 mRNA]PMID:21233418
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