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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350018
Species: Homo sapiens
RGD Object: Gene
Symbol: UGT1A1
Name: UDP glucuronosyltransferase family 1 member A1
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
UGT1A1decreases expressionEXP 6480464CTDafimoxifene results in decreased expression of UGT1A1 mRNAPMID:15072547
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