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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingISORGD:25826480464CTDafimoxifene binds to ESR2 protein

PMID:19913605
affects bindingISORGD:692136480464CTDafimoxifene binds to ESR2 protein

PMID:17203231, PMID:19913605, PMID:9751507
affects expressionISORGD:692136480464CTDafimoxifene affects the expression of ESR2 protein

PMID:15721411
increases response to substanceISORGD:692136480464CTDESR2 protein results in increased susceptibility to afimoxifene

PMID:15821116
multiple interactionsISORGD:25826480464CTDafimoxifene inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein], afimoxifene inhibits the reaction [Estradiol binds to ESR2 protein alternative form]

PMID:9048584, PMID:9492041
multiple interactionsISORGD:692136480464CTDafimoxifene binds to and results in decreased activity of ESR2 protein, afimoxifene inhibits the reaction [Estradiol binds to ESR2 protein], afimoxifene inhibits the reaction [Estradiol results in increased activity of ESR2 protein], afimoxifene inhibits the reaction [methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]]

PMID:15103026, PMID:15537743, PMID:28248286, PMID:9751507
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.