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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10512
Species: Mus musculus
RGD Object: Gene
Symbol: Egr1
Name: early growth response 1
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egr1increases expressionISOEGR1 (Homo sapiens)6480464CTDafimoxifene results in increased expression of EGR1 mRNAPMID:19153601
Egr1multiple interactionsISOEGR1 (Homo sapiens)6480464CTD[BRAF protein co-treated with afimoxifene] results in increased expression of and results in increased activity of EGR1 protein; GPER1 protein affects the reaction [afimoxifene results in increased expression of EGR1 mRNA]PMID:19153601 PMID:25645941
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