Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7368326480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein], [afimoxifene co-treated with EGF protein] results in increased expression of CDH1 mRNA, [afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein, AG 1879 inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein], fulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]

PMID:19593637
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.