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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:44445
Term: nimesulide
Definition: An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Chemical ID: MESH:C012655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:104736480464CTDnimesulide results in increased expression of NQO1

PMID:20405857
increases expressionISORGD:25036480464CTDnimesulide results in increased expression of NQO1 mRNA

PMID:24136188
multiple interactionsISORGD:104736480464CTDNFE2L2 mutant form inhibits the reaction [nimesulide results in increased expression of NQO1]

PMID:20405857
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.