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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69168
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARG
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:44445
Term: nimesulide
Definition: An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Chemical ID: MESH:C012655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGdecreases expressionEXP 6480464CTDnimesulide results in decreased expression of PPARG mRNAPMID:11840453
PPARGincreases expressionEXP 6480464CTDnimesulide results in increased expression of PPARG proteinPMID:14977856
PPARGmultiple interactionsEXP 6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [nimesulide promotes the reaction [PPARG binds to PPARG promoter]]; [nimesulide co-treated with Doxorubicin] results in increased expression of PPARG; nimesulide inhibits the reaction [ciglitazone promotes the reaction [PPARG protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [ciglitazone results in increased expression of PPARG mRNA]; nimesulide inhibits the reaction [pirinixic acid promotes the reaction [PPARG protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [pirinixic acid results in increased expression of PPARG mRNA]; nimesulide promotes the reaction [PPARG binds to PPARG promoter]; PPARG mutant form inhibits the reaction [nimesulide results in increased expression of PPARG mRNA]PMID:11840453 PMID:14567645 PMID:15705899
PPARGincreases expressionISOPparg (Mus musculus)6480464CTDnimesulide results in increased expression of PPARG mRNAPMID:15705899
PPARGmultiple interactionsISOPparg (Rattus norvegicus)6480464CTDnimesulide inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA]PMID:19247274
PPARGmultiple interactionsISOPparg (Mus musculus)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [nimesulide results in increased expression of PPARG mRNA]PMID:15705899
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