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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:44445
Term: nimesulide
Definition: An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Chemical ID: MESH:C012655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngdecreases expressionEXP 6480464CTDnimesulide results in decreased expression of IFNGPMID:24136188
Ifngmultiple interactionsEXP 6480464CTDnimesulide inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Dinoprostone]PMID:12911628
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTD[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to nimesulidePMID:19362101
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTD[nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of IFNG mRNAPMID:22561872
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