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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2457
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Acc ID: CHEBI:44445
Term: nimesulide
Definition: An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Chemical ID: MESH:C012655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp19a1decreases activityEXP 6480464CTDnimesulide results in decreased activity of CYP19A1 proteinPMID:23054057
Cyp19a1decreases activityISOCYP19A1 (Homo sapiens)6480464CTDnimesulide analog results in decreased activity of CYP19A1 protein; nimesulide results in decreased activity of CYP19A1; nimesulide results in decreased activity of CYP19A1 proteinPMID:15964185 PMID:17315855 PMID:20542113
Cyp19a1decreases expressionISOCYP19A1 (Homo sapiens)6480464CTDnimesulide analog results in decreased expression of CYP19A1 mRNA; nimesulide results in decreased expression of CYP19A1 mRNAPMID:15964185 PMID:20542113
Cyp19a1multiple interactionsISOCYP19A1 (Homo sapiens)6480464CTDnimesulide analog results in decreased activity of and results in decreased expression of CYP19A1PMID:17315855
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