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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:44445
Term: nimesulide
Definition: An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Chemical ID: MESH:C012655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases expressionEXP 6480464CTDnimesulide results in increased expression of PARP1 mRNAPMID:24136188
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDnimesulide results in increased cleavage of PARP1 proteinPMID:19360361
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