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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557923
Species: Mus musculus
RGD Object: Gene
Symbol: Atr
Name: ataxia telangiectasia and Rad3 related
Acc ID: CHEBI:44442
Term: 6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine
Definition: null
Chemical ID: MESH:C475622
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:13140476480464CTD4-cyclohexylmethoxy-5-nitrosopyrimidine-2, 6-diamine results in decreased activity of ATR

PMID:21730979
multiple interactionsISORGD:13140476480464CTD4-cyclohexylmethoxy-5-nitrosopyrimidine-2, 6-diamine inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of ATR protein], 4-cyclohexylmethoxy-5-nitrosopyrimidine-2, 6-diamine inhibits the reaction [trovafloxacin results in increased phosphorylation of ATR protein], [4-cyclohexylmethoxy-5-nitrosopyrimidine-2, 6-diamine results in decreased activity of ATR] which results in increased susceptibility to Cisplatin, [4-cyclohexylmethoxy-5-nitrosopyrimidine-2, 6-diamine results in decreased activity of ATR] which results in increased susceptibility to Hydroxyurea, [4-cyclohexylmethoxy-5-nitrosopyrimidine-2, 6-diamine results in decreased activity of ATR] which results in increased susceptibility to temozolomide

PMID:21730979, PMID:25748550
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.