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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:44423
Term: hydroxyurea
Definition: A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.
Chemical ID: MESH:D006918
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axincreases expressionISOH2AX (Homo sapiens)6480464CTDHydroxyurea results in increased expression of H2AX protein; Hydroxyurea results in increased expression of H2AX protein modified formPMID:21840268 PMID:25125662 PMID:25130544
H2axincreases phosphorylationISOH2AX (Homo sapiens)6480464CTDHydroxyurea results in increased phosphorylation of H2AX proteinPMID:32466334 PMID:32482060
H2axincreases phosphorylationISOH2ax (Mus musculus)6480464CTDHydroxyurea results in increased phosphorylation of H2AX proteinPMID:29228353
H2axmultiple interactionsISOH2ax (Mus musculus)6480464CTDTRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased phosphorylation of H2AX protein]PMID:29228353
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