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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317959
Species: Homo sapiens
RGD Object: Gene
Symbol: AKR1B10
Name: aldo-keto reductase family 1 member B10
Acc ID: CHEBI:44409
Term: NADP zwitterion
Definition: A NADP that has formula 743.40528.
Chemical ID: MESH:D009249
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1B10affects bindingEXP 6480464CTDNADP binds to AKR1B10 protein mutant form binds to fidarestat

PMID:23295227
AKR1B10decreases reductionEXP 6480464CTDAKR1B10 protein results in decreased reduction of NADP

PMID:19013440
AKR1B10increases activityEXP 6480464CTDNADP results in increased activity of AKR1B10 protein

PMID:23295224
AKR1B10multiple interactionsEXP 6480464CTD[AKR1B10 protein co-treated with NADP] affects the reduction of Glyceraldehyde, [AKR1B10 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7, 8-dihydrodiol, [AKR1B10 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7, 8-dione

PMID:17329238, PMID:21910479
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.