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RGD ID: 1317959
Species: Homo sapiens
RGD Object: Gene
Symbol: AKR1B10
Name: aldo-keto reductase family 1 member B10
Acc ID: CHEBI:44409
Term: NADP zwitterion
Definition: A NADP that has formula 743.40528.
Chemical ID: MESH:D009249
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1B10affects bindingEXP 6480464CTDNADP binds to AKR1B10 protein mutant form binds to fidarestat

AKR1B10decreases reductionEXP 6480464CTDAKR1B10 protein results in decreased reduction of NADP

AKR1B10increases activityEXP 6480464CTDNADP results in increased activity of AKR1B10 protein

AKR1B10multiple interactionsEXP 6480464CTD[AKR1B10 protein co-treated with NADP] affects the reduction of Glyceraldehyde, [AKR1B10 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7, 8-dihydrodiol, [AKR1B10 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7, 8-dione

PMID:17329238, PMID:21910479
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.