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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315696
Species: Mus musculus
RGD Object: Gene
Symbol: Akr1c6
Name: aldo-keto reductase family 1, member C6
Acc ID: CHEBI:44409
Term: NADP zwitterion
Definition: A NADP that has formula 743.40528.
Chemical ID: MESH:D009249
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c6multiple interactionsISOAKR1C4 (Homo sapiens)6480464CTD[AKR1C4 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol; [AKR1C4 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione; NADP inhibits the reaction [AKR1C4 protein results in increased oxidation of Hydroxysteroids]PMID:14672942 PMID:21910479
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