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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif3a
Name: hypoxia inducible factor 3 subunit alpha
Acc ID: CHEBI:44241
Term: metyrapone
Definition: An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Chemical ID: MESH:D008797
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDMetyrapone inhibits the reaction [Ozone results in increased expression of HIF3A mRNA]

PMID:27037194
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