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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735754
Species: Homo sapiens
RGD Object: Gene
Symbol: SFRP1
Name: secreted frizzled related protein 1
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SFRP1increases expressionISOSfrp1 (Rattus norvegicus)6480464CTDMethotrexate results in increased expression of SFRP1 mRNA; Methotrexate results in increased expression of SFRP1 proteinPMID:25187349
SFRP1multiple interactionsISOSfrp1 (Rattus norvegicus)6480464CTDLeucovorin inhibits the reaction [Methotrexate results in increased expression of SFRP1 mRNA]; Leucovorin inhibits the reaction [Methotrexate results in increased expression of SFRP1 protein]PMID:25187349
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