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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735707
Species: Homo sapiens
RGD Object: Gene
Symbol: IL1A
Name: interleukin 1 alpha
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1Adecreases expressionEXP 6480464CTDMethotrexate results in decreased expression of IL1A mRNAPMID:17400583
IL1Aincreases expressionEXP 6480464CTDMethotrexate results in increased expression of IL1A mRNAPMID:17379860 PMID:19100307 PMID:24657277
IL1Amultiple interactionsEXP 6480464CTD[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of IL1A mRNAPMID:24657277
IL1Amultiple interactionsISOIl1a (Mus musculus)6480464CTD[Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL1A proteinPMID:31651976
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