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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735591
Species: Homo sapiens
RGD Object: Gene
Symbol: IL10
Name: interleukin 10
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL10increases expressionEXP 6480464CTDMethotrexate results in increased expression of IL10 proteinPMID:19100307
IL10multiple interactionsEXP 6480464CTDMethotrexate results in decreased expression of and results in decreased secretion of IL10 protein; SB 203580 inhibits the reaction [Methotrexate results in increased expression of IL10 protein]PMID:19100307 PMID:25330300
IL10decreases expressionISOIl10 (Rattus norvegicus)6480464CTDMethotrexate results in decreased expression of IL10 proteinPMID:34737150
IL10decreases secretionISOIl10 (Rattus norvegicus)6480464CTDMethotrexate results in decreased secretion of IL10 proteinPMID:20885979
IL10multiple interactionsISOIl10 (Mus musculus)6480464CTD[Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL10 proteinPMID:31651976
IL10multiple interactionsISOIl10 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Methotrexate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Methotrexate results in decreased secretion of IL10 protein]; Perindopril inhibits the reaction [Methotrexate results in decreased expression of IL10 protein]PMID:20885979 PMID:34737150
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