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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732271
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK8multiple interactionsEXP 6480464CTDMAPK8 gene mutant form inhibits the reaction [Methotrexate results in increased expression of CDKN1A protein]PMID:22183962
MAPK8increases phosphorylationISOMapk8 (Rattus norvegicus)6480464CTDMethotrexate results in increased phosphorylation of MAPK8 proteinPMID:20885979
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