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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730855
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD1
Name: superoxide dismutase 1
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD1increases expressionEXP 6480464CTDMethotrexate results in increased expression of SOD1 mRNAPMID:29027214
SOD1decreases response to substanceISOSod1 (Mus musculus)6480464CTDSOD1 mRNA results in decreased susceptibility to MethotrexatePMID:16918715
SOD1increases expressionISOSod1 (Rattus norvegicus)6480464CTDMethotrexate results in increased expression of SOD1 mRNAPMID:29027214
SOD1multiple interactionsISOSod1 (Rattus norvegicus)6480464CTDCaptopril inhibits the reaction [Methotrexate results in decreased expression of and results in decreased activity of SOD1 protein]; Methotrexate results in decreased expression of and results in decreased activity of SOD1 protein; Telmisartan inhibits the reaction [Methotrexate results in decreased expression of and results in decreased activity of SOD1 protein]PMID:27269004
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