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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70879
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atic
Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aticaffects response to substanceISOATIC (Homo sapiens)6480464CTDATIC gene polymorphism affects the susceptibility to Methotrexate; ATIC gene SNP affects the susceptibility to MethotrexatePMID:16947783 PMID:17410198 PMID:17530705
Aticdecreases expressionISOATIC (Homo sapiens)6480464CTDMethotrexate results in decreased expression of ATIC mRNAPMID:23897011
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