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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl2multiple interactionsEXP 6480464CTDMethotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of CXCL2 protein]PMID:32061742
Cxcl2decreases expressionISOCXCL2 (Homo sapiens)6480464CTDMethotrexate results in decreased expression of CXCL2 mRNAPMID:24449571
Cxcl2multiple interactionsISOCXCL2 (Homo sapiens)6480464CTD[Methotrexate analog binds to Lipids] which results in decreased expression of CXCL2 mRNAPMID:24065615
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