Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	69093
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	HNF4A
Name:	hepatocyte nuclear factor 4 alpha

Acc ID:	CHEBI:44185
Term:	methotrexate
Definition:	A pteridine that has formula C20H22N8O5.
Chemical ID:	MESH:D008727

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
HNF4A	increases secretion	ISO	Hnf4a (Mus musculus)	6480464	CTD	HNF4A protein results in increased secretion of Methotrexate	PMID:27160211

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.