GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | increases expression | EXP | | 6480464 | CTD | Methotrexate results in increased expression of BAX mRNA; Methotrexate results in increased expression of BAX protein | PMID:18803016 PMID:28414158 PMID:28479099 PMID:29027214 PMID:31362085 PMID:33720507 PMID:37312617 | Bax | multiple interactions | EXP | | 6480464 | CTD | 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]; [Aspartame co-treated with Methotrexate] results in increased expression of BAX mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of BAX protein; Carnitine inhibits the reaction [Methotrexate results in increased expression of BAX protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]; Liraglutide inhibits the reaction [Methotrexate results in increased expression of BAX protein]; Methotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of BAX protein]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]; TGFA protein inhibits the reaction [Methotrexate results in increased expression of BAX mRNA]; TGFA protein inhibits the reaction [Methotrexate results in increased expression of BAX protein] | PMID:18803016 PMID:25009784 PMID:28414158 PMID:28479099 PMID:30025850 PMID:31362085 PMID:33720507 PMID:37312617 | Bax | affects expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Methotrexate affects the expression of BAX mRNA | PMID:23792648 PMID:25330300 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Methotrexate results in increased expression of BAX mRNA | PMID:23836430 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Methotrexate results in increased expression of BAX mRNA | PMID:21678067 PMID:29027214 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | SOD2 protein polymorphism affects the reaction [Methotrexate affects the expression of BAX mRNA] | PMID:25330300 | |
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