GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mpo | increases activity | EXP | | 6480464 | CTD | Methotrexate results in increased activity of MPO protein | PMID:20816014 PMID:27377006 | Mpo | increases expression | EXP | | 6480464 | CTD | Methotrexate results in increased expression of MPO; Methotrexate results in increased expression of MPO protein | PMID:20885979 PMID:26517535 PMID:33720507 | Mpo | multiple interactions | EXP | | 6480464 | CTD | Acetylcysteine inhibits the reaction [Methotrexate results in increased expression of MPO protein]; Curcumin inhibits the reaction [Methotrexate results in increased expression of MPO protein]; Methotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of MPO protein]; Resveratrol inhibits the reaction [Methotrexate results in increased expression of MPO]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of MPO protein] | PMID:20885979 PMID:26517535 PMID:32061742 PMID:33720507 | | ||||||||||||||||||||||
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