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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564525
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mxd1
Name: max dimerization protein 1
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:13536086480464CTDMXD1 mRNA affects the susceptibility to Methotrexate

PMID:22753658
increases expressionISORGD:13536086480464CTDMethotrexate results in increased expression of MXD1 mRNA

PMID:21678067, PMID:24657277
multiple interactionsISORGD:13536086480464CTD[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of MXD1 mRNA

PMID:24657277
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.