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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11219
Species: Mus musculus
RGD Object: Gene
Symbol: Rb1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rb1increases phosphorylationEXP 6480464CTDMethotrexate results in increased phosphorylation of RB1 proteinPMID:22484375
Rb1affects response to substanceISORB1 (Homo sapiens)6480464CTDRB1 gene affects the susceptibility to Methotrexate; RB1 protein affects the susceptibility to MethotrexatePMID:12972956 PMID:14679136
Rb1increases phosphorylationISORB1 (Homo sapiens)6480464CTDMethotrexate results in increased phosphorylation of RB1 proteinPMID:22484375
Rb1increases response to substanceISORB1 (Homo sapiens)6480464CTDRB1 protein results in increased susceptibility to MethotrexatePMID:14534726
Rb1multiple interactionsISORB1 (Homo sapiens)6480464CTDMethotrexate inhibits the reaction [RB1 protein binds to E2F1 protein]PMID:22484375
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