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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1596276
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Haspin
Name: histone H3 associated protein kinase
Acc ID: CHEBI:4393
Term: (-)-demecolcine
Definition: A secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic.
Chemical ID: MESH:D003703
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13530916480464CTDDemecolcine results in decreased expression of HASPIN mRNA

PMID:23649840
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.