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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11414
Species: Mus musculus
RGD Object: Gene
Symbol: Th
Name: tyrosine hydroxylase
Acc ID: CHEBI:43871
Term: fasudil
Definition: An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Chemical ID: MESH:C049347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thmultiple interactionsISOTh (Rattus norvegicus)6480464CTD[[propionic acid co-treated with fasudil] affects the susceptibility to Rotenone] which results in increased expression of TH mRNAPMID:32481507
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