GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1h4 | increases expression | ISO | Nr1h4 (Rattus norvegicus) | 1625201 | RGD | obeticholic acid increases expression of Nr1H4 mRNA in rat hepatic stellate cells; obeticholic acid increases expression of Nr1h4 mRNA in bile duct ligation and porcine serum induced models of cirrhosis in rat | | Nr1h4 | multiple interactions | ISO | Nr1h4 (Rattus norvegicus) | 15036816 | RGD | Obeticholic acid inhibits the reaction [ethanol decreases expression of Nr1h4 mRNA and protein in liver and liver cell nuclei and intestine] | | Nr1h4 | increases activity | EXP | | 6480464 | CTD | obeticholic acid results in increased activity of NR1H4 protein | PMID:35688268 | Nr1h4 | increases expression | EXP | | 6480464 | CTD | obeticholic acid results in increased expression of NR1H4 protein | PMID:27865854 | Nr1h4 | increases response to substance | EXP | | 6480464 | CTD | NR1H4 protein results in increased susceptibility to obeticholic acid | PMID:21242261 | Nr1h4 | multiple interactions | EXP | | 6480464 | CTD | [obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of NR1H4 protein; NR1H4 affects the reaction [obeticholic acid results in increased expression of FOXM1 mRNA]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FABP6 mRNA]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FGF15 mRNA]; NR1H4 promotes the reaction [obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]]; obeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of NR1H4 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of NR1H4 protein] | PMID:22135065 PMID:22918042 PMID:29660435 PMID:35688268 PMID:36328986 PMID:36787806 | Nr1h4 | increases activity | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | obeticholic acid results in increased activity of NR1H4 protein | PMID:15911693 PMID:17567710 PMID:27871908 | Nr1h4 | increases expression | ISO | Nr1h4 (Rattus norvegicus) | 6480464 | CTD | obeticholic acid results in increased expression of NR1H4 mRNA | PMID:15860571 PMID:15980055 PMID:27255380 | Nr1h4 | multiple interactions | ISO | Nr1h4 (Rattus norvegicus) | 6480464 | CTD | obeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR1H4 mRNA] | PMID:22918042 PMID:27255380 PMID:32673658 | Nr1h4 | multiple interactions | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | obeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid promotes the reaction [NR1H4 protein binds to PRMT1 protein] | PMID:15911693 PMID:22918042 PMID:28887089 PMID:29660435 | |
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