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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737414
Species: Mus musculus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:4357
Term: deguelin
Definition: A rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers.
Chemical ID: MESH:C107676
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh1affects localizationISOCDH1 (Homo sapiens)6480464CTDdeguelin affects the localization of CDH1 proteinPMID:22986522
Cdh1increases expressionISOCDH1 (Homo sapiens)6480464CTDdeguelin results in increased expression of CDH1 mRNA; deguelin results in increased expression of CDH1 proteinPMID:22986522 PMID:28509438
Cdh1multiple interactionsISOCDH1 (Homo sapiens)6480464CTDdeguelin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; deguelin promotes the reaction [CTNNB1 protein binds to CDH1 protein]PMID:22986522
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