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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:4357
Term: deguelin
Definition: A rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers.
Chemical ID: MESH:C107676
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1aincreases degradationISOHIF1A (Homo sapiens)6480464CTDdeguelin results in increased degradation of HIF1A proteinPMID:17764071
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of HIF1A protein]; deguelin inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; deguelin metabolite inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]PMID:17764071 PMID:18575727 PMID:19139008 PMID:22745725 PMID:27899277
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