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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68595
Species: Mus musculus
RGD Object: Gene
Symbol: Epas1
Name: endothelial PAS domain protein 1
Acc ID: CHEBI:4356
Term: desferrioxamine B
Definition: An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Chemical ID: MESH:D003676
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Epas1increases expressionISOEpas1 (Rattus norvegicus)6480464CTDDeferoxamine results in increased expression of EPAS1 proteinPMID:18353899 PMID:21558026
Epas1increases expressionISOEPAS1 (Homo sapiens)6480464CTDDeferoxamine results in increased expression of EPAS1 proteinPMID:22447124 PMID:26735578 PMID:27287256
Epas1increases stabilityISOEPAS1 (Homo sapiens)6480464CTDDeferoxamine results in increased stability of EPAS1 proteinPMID:18515279
Epas1multiple interactionsISOEPAS1 (Homo sapiens)6480464CTDDeferoxamine inhibits the reaction [EPAS1 protein results in increased degradation of COX4I1 protein]PMID:18515279
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