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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mgmt
Name: O-6-methylguanine-DNA methyltransferase
Acc ID: CHEBI:4305
Term: dacarbazine
Definition: A monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma.
Chemical ID: MESH:D003606
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mgmtaffects response to substanceISORGD:7359046480464CTDMGMT protein affects the susceptibility to Dacarbazine

PMID:14562026
Mgmtdecreases activityISORGD:7359046480464CTDDacarbazine results in decreased activity of MGMT protein

PMID:12494480
Mgmtdecreases expressionISORGD:7359046480464CTDDacarbazine results in decreased expression of MGMT protein

PMID:12494480
Mgmtdecreases response to substanceISORGD:7359046480464CTDMGMT protein results in decreased susceptibility to Dacarbazine

PMID:10751609 PMID:12170182 PMID:15870882
Mgmtincreases response to substanceISORGD:108966480464CTDMGMT gene mutant form results in increased susceptibility to Dacarbazine

PMID:11023546 PMID:15010317
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