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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10531
Species: Mus musculus
RGD Object: Gene
Symbol: Epo
Name: erythropoietin
Acc ID: CHEBI:43029
Term: L-erythro-7,8-dihydrobiopterin
Definition: A 7,8-dihydrobiopterin in which the 1,2-dihydroxypropyl group has (1R,2S)-configuration; naturally occurring form.
Chemical ID: MESH:C017226
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Epomultiple interactionsEXP 6480464CTDEPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; EPO protein inhibits the reaction [HPH1 gene mutant form results in increased abundance of 7,8-dihydrobiopterin]PMID:25041251 PMID:25490417
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