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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732740
Species: Homo sapiens
RGD Object: Gene
Symbol: CAT
Name: catalase
Acc ID: CHEBI:42839
Term: 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine
Definition: Puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring.
Chemical ID: MESH:D011692
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CATaffects activityISOCat (Rattus norvegicus)6480464CTDPuromycin Aminonucleoside affects the activity of CAT proteinPMID:6246912
CATdecreases activityISOCat (Rattus norvegicus)6480464CTDPuromycin Aminonucleoside results in decreased activity of CAT proteinPMID:10468195 PMID:15113391 PMID:1744988 PMID:8289993
CATdecreases expressionISOCat (Rattus norvegicus)6480464CTDPuromycin Aminonucleoside results in decreased expression of CAT mRNAPMID:20685819
CATincreases activityISOCat (Mus musculus)6480464CTDPuromycin Aminonucleoside results in increased activity of CAT proteinPMID:15496159
CATmultiple interactionsISOCat (Rattus norvegicus)6480464CTD[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of CAT protein; Cyclosporine inhibits the reaction [Puromycin Aminonucleoside results in decreased activity of CAT protein]; Puromycin Aminonucleoside results in decreased expression of and results in decreased activity of CAT protein; sho-saiko-to-kyo-shokyo-ka-oren-bukuryo inhibits the reaction [Puromycin Aminonucleoside results in decreased activity of CAT protein]PMID:1744988 PMID:1942778 PMID:8289993 PMID:9355075
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