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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cacna2d2
Name: calcium voltage-gated channel auxiliary subunit alpha2delta 2
Acc ID: CHEBI:42797
Term: gabapentin
Definition: A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Chemical ID: MESH:C040029
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects activityISORGD:13322106480464CTDCACNA2D2 protein affects the activity of gabapentin

PMID:14660671
affects bindingISORGD:7376096480464CTDgabapentin binds to CACNA2D2 protein

PMID:11687876
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.