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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2247
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cacna2d1
Name: calcium voltage-gated channel auxiliary subunit alpha2delta 1
Acc ID: CHEBI:42797
Term: gabapentin
Definition: A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Chemical ID: MESH:C040029
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cacna2d1affects bindingEXP 6480464CTDgabapentin binds to CACNA2D1 protein

PMID:16380257
Cacna2d1multiple interactionsEXP 6480464CTDCACNA2D1 protein results in increased susceptibility to [gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]]

PMID:19796812
Cacna2d1affects bindingISORGD:102696480464CTDgabapentin binds to CACNA2D1 protein

PMID:16380257
Cacna2d1multiple interactionsISORGD:102696480464CTD[gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Methamphetamine [gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Potassium Chloride [gabapentin results in decreased activity of CACNA2D1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium] gabapentin inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]

PMID:17442347 PMID:17881535 PMID:20340177 PMID:21182903
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