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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:42768
Term: geneticin
Definition: An aminoglycoside antibiotic produced by Micromonospora rhodorangea. It blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.
Chemical ID: MESH:C010680
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases cleavageISORGD:13480776480464CTDantibiotic G 418 results in increased cleavage of CASP12 protein

PMID:15241557
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.