GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GCK | decreases expression | ISO | Gck (Rattus norvegicus) | 6480464 | CTD | Glucose results in decreased expression of GCK mRNA | PMID:31974165 | GCK | increases expression | ISO | Gck (Rattus norvegicus) | 6480464 | CTD | Glucose results in increased expression of GCK mRNA | PMID:24349266 | GCK | multiple interactions | ISO | Gck (Rattus norvegicus) | 6480464 | CTD | Glucose results in decreased expression of and affects the localization of GCK protein; Metformin inhibits the reaction [Glucose results in decreased expression of GCK mRNA] | PMID:31974165 | GCK | multiple interactions | ISO | Gck (Mus musculus) | 6480464 | CTD | [ebselen co-treated with Glucose] results in increased activity of GCK protein; [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Herbicides] results in increased expression of GCK mRNA; Glucose inhibits the reaction [Alloxan results in decreased expression of GCK mRNA] | PMID:12137914 PMID:23795780 PMID:37567420 | | ||||||||||||||||||||||
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