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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732481
Species: Mus musculus
RGD Object: Gene
Symbol: Hspb1
Name: heat shock protein 1
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspb1increases phosphorylationISOHSPB1 (Homo sapiens)6480464CTDGlucose results in increased phosphorylation of HSPB1 proteinPMID:25373458
Hspb1increases secretionISOHSPB1 (Homo sapiens)6480464CTDGlucose deficiency results in increased secretion of HSPB1 proteinPMID:24802182
Hspb1multiple interactionsISOHspb1 (Rattus norvegicus)6480464CTD[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HSPB1 mRNA; [Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HSPB1 protein; resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HSPB1 mRNA]; resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HSPB1 protein]PMID:23421680
Hspb1multiple interactionsISOHSPB1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of HSPB1 protein]; U 0126 inhibits the reaction [Glucose results in increased phosphorylation of HSPB1 protein]PMID:25373458
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