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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69659
Species: Homo sapiens
RGD Object: Gene
Symbol: ICAM1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ICAM1increases expressionEXP 6480464CTDGlucose results in increased expression of ICAM1; Glucose results in increased expression of ICAM1 mRNA; Glucose results in increased expression of ICAM1 proteinPMID:15304054 PMID:16285992 PMID:21367880 PMID:21373835 PMID:21682256 PMID:22074828 PMID:23111892 PMID:23329836 PMID:24436987 PMID:24513509 PMID:25338943
ICAM1increases secretionEXP 6480464CTDGlucose results in increased secretion of ICAM1 proteinPMID:15304054
ICAM1multiple interactionsEXP 6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Glucose results in increased expression of ICAM1]; 5,21 - 12,17-dimetheneo-18H-dibenzo(i,o)pyrrolo(3,4-1)(1,8)diazacyclohexandecine-18,10(19H)dione,8((dimethylamino)methyl)-6,7,8,9,10,11-hexahydro,monomethanesulfonate inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; 5,21 - 12,17-dimetheneo-18H-dibenzo(i,o)pyrrolo(3,4-1)(1,8)diazacyclohexandecine-18,10(19H)dione,8((dimethylamino)methyl)-6,7,8,9,10,11-hexahydro,monomethanesulfonate inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; [Resveratrol affects the localization of RELA protein] inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; [Resveratrol affects the localization of RELA protein] inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; aspalathin inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [Glucose results in increased expression of ICAM1]; HTS 466284 inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; isoangustone A inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; manganese chloride inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; Mannitol inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Glucose results in increased secretion of ICAM1 protein]; naringin inhibits the reaction [Glucose results in increased expression of ICAM1]; nothofagin inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; Polyphenols inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Resveratrol inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Resveratrol inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of ICAM1]; Rimonabant inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; sarpogrelate inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; Thenoyltrifluoroacetone inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Thenoyltrifluoroacetone inhibits the reaction [Glucose results in increased expression of ICAM1 protein]PMID:15304054 PMID:16285992 PMID:21367880 PMID:21373835 PMID:21682256 PMID:22074828 PMID:23111892 PMID:23329836 PMID:24436987 PMID:24513509 PMID:25338943
ICAM1increases expressionISOIcam1 (Rattus norvegicus)6480464CTDGlucose results in increased expression of ICAM1 mRNA; Glucose results in increased expression of ICAM1 proteinPMID:23376009 PMID:28700904
ICAM1multiple interactionsISOIcam1 (Rattus norvegicus)6480464CTDCurcumin analog inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Y 27632 inhibits the reaction [Glucose results in increased expression of ICAM1 protein]PMID:23376009 PMID:28700904
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